A Cytoplasmically Transmitted, Diet-Dependent Difference in Response to the Teratogenic Effects of 6-Aminonicotinamide
- 12 April 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 160 (3824) , 206-207
- https://doi.org/10.1126/science.160.3824.206
Abstract
The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F1 mothers are maintained on Lab Chow but not on Breeder Chow.Keywords
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