Negative regulation of the anti‐human immunodeficiency virus and chemotactic activity of human stromal cell‐derived factor 1α by CD26/dipeptidyl peptidase IV
- 17 July 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 431 (2) , 236-240
- https://doi.org/10.1016/s0014-5793(98)00763-7
Abstract
Stromal cell-derived factor 1α (SDF-1α) is a chemokine that has been shown to prevent infection of T-tropic HIV strains and is a possible substrate of CD26/dipeptidyl peptidase IV (DPPIV). In this study, we show that SDF-1α was cleaved at the N-terminal region by CD26/DPPIV and as a result the inhibitory activity of SDF-1α against HIV infection disappeared. Moreover, the chemotactic activity of SDF-1α also disappeared specifically by DPPIV activity of recombinant soluble CD26. These results suggested that dissemination of T-tropic HIV strains in vivo may be facilitated by CD26/DPPIV via inactivation of functional SDF-1αKeywords
This publication has 32 references indexed in Scilit:
- Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated CleavageThe Journal of Experimental Medicine, 1997
- The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entryNature, 1996
- The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 IsolatesPublished by Elsevier ,1996
- CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1Science, 1996
- A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion CofactorsCell, 1996
- Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T CellsScience, 1995
- Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26Science, 1993
- A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase.The Journal of Experimental Medicine, 1993
- Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesisBiochemistry, 1992
- Biochemical characterization of CD26 (dipeptidyl peptidase IV): Functional comparison of distinct epitopes recognized by various anti-CD26 monoclonal antibodiesMolecular Immunology, 1992