INCREASED RELATIVE EFFECTIVENESS OF DOXORUBICIN AGAINST SLOWLY PROLIFERATING SARCOMA-180 CELLS AFTER PROLONGED DRUG EXPOSURE
- 1 January 1982
- journal article
- research article
- Vol. 66 (5) , 1159-1168
Abstract
Doxorubicin [adriamycin] (ADR) lethality was studied in [mouse] Sarcoma 180 cells grown in vitro during log phase and early plataeu phase. For both log phase and plateau phase cells, ADR lethality increased progressively with continuous drug exposure, and was dependent on drug concentration at every point in time. For any given level of toxicity to log phase cells, greater killing of plateau phase cells was achieved with prolonged drug exposure. The inhibition of DNA synthesis by ADR was delayed in onset, and increased gradually, both at low and high drug concentrations. The dependence of ADR lethality on proliferation rate and the higher therapeutic ratio in plateau phase cells with prolonged drug exposure probably are not directly related to the ADR effects on DNA synthesis.This publication has 6 references indexed in Scilit:
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