PRODUCTION OF EXPERIMENTAL TOXEMIA IN PREGNANT DOG

  • 1 January 1976
    • journal article
    • research article
    • Vol. 48  (5) , 537-548
Abstract
The aortas of 14 pregnant bitches were treated 1-3 wk before term, producing a stricture that reduced the lumen from an average normal of 7-11 mm to 2.1 mm in diameter. Nine animals developed hypertension, 3 had significant proteinuria and 1 had fluid retention. Light microscopy revealed moderate or severe glomerular lesions in 9 animals characterized by endothelial cell swelling, mesangial cell proliferation and focal basement membrane thickening; EM revealed mesangial enlargement and electron-dense deposits. Immunofluorescence with rabbit anti-dog fibrinogen showed glomerular deposition of fibrinogen or its breakdown products in 11 of 12 cases so studied. Focal necrosis was seen in the liver in 5 cases, and diffuse hemorrhagic infarction of the placenta was present in all animals. None of these changes was found in nonpregnant or in sham-operated controls.

This publication has 2 references indexed in Scilit: