Further Evidence on the Effect of Vitamin E on the Cholesterol Distribution in Lipoproteins with Special Reference to HDL Subfractions
Open Access
- 1 May 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 79 (5) , 604-606
- https://doi.org/10.1093/ajcp/79.5.604
Abstract
Earlier claims that oral administration of α-tocopherol results in significant and considerable increase in the serum total HDL concentration could not be substantiated. The present investigation does, however, show that lipoproteins are affected by α-tocopherol in other ways, the main effects being an increase in LDL-cholesterol and also in the HDL3-v cholesterol, an HDL3-subfraction determined by polyacrylamide gel electrophoresis. The established lipoprotein risk indices (LDL/HDL and HDL3/HDL2 ratios) were unfavorably affected as a result of α-tocopherol treatment. It is concluded that on the basis of available evidence, there is no reason to believe that α-tocopherol has a role to play in the prevention and treatment of atherosclerotic disease.Keywords
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