Ontogeny of Physiological Regulations in the Rat

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Abstract
The development of body regulations of heat, oxygen, and water in the rat are discussed and compared. Factors considered under heat regulation include heat production, oxygen consumption, extra metabolism in cold surroundings, heat loss, insulation, cooling rates, nervous factors, adrenal activities, lethal body temperatures, and the effects of body temperatures on pulse rate, oxygen consumption and breathing. Important considerations in oxygen consumption are blood composition, the relation between tolerance to anoxia and tolerance to hypothermia, the composition of the brain and its enzymic activities, chemo-reflexes, respiration processes, and tissue metabolism in general. Water and salt diuresis, blood-circulatory factors, renal structures and activities, and water intake are factors discussed under water regulation. Each of the above regulatory factors undergoes progressive changes during the early life of the animal.

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