Demonstration of projections from locus coeruleus to supraoptic nucleus by the HRP method with special reference to cell types in the rat.

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Abstract
Histochemical studies were conducted on the distribution of labeled neurons in the rat pons at the level of the locus coerueleus after HRP [horseradish peroxidase] injections into the supraoptic nucleus. In all 15 cases in which the supraoptic nucleus was included in the injection site, labeled neurons were detected in the locus coeruleus. In the other 9 cases in which the injection site was outside the supraoptic nucleus, labeled neurons were not detected in the locus coeruleus. Six cases having the injection site successfully localized within the supraoptic nucleus showed definitely a few labeled multipolar neurons only in the ipsilateral locus coeruleus. The presence of an efferent projection arising from the locus coeruleus to the ipsilateral supraoptic nucleus is demonstrated. Mainly multipolar neurons in both divisions of this nucleus may contribute to this projection. The locus coeruleus may project to the supraoptic nucleus on the contralateral side.