Effects of renal venous occlusion on renal hemodynamics and concentrating ability

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Abstract
Following periods of occlusion of 2–30 min, blood flow showed a phase of increase which was greatest after the short periods of blockade, and became progressively less with longer periods of occlusion. Minimal impairment of clearances resulted from 2 to 5 min of obstruction, but significant and prolonged decrements followed 15- and 30-min periods. Urine volume, CNa, Cosm, and TcHH2O were also markedly decreased after the longer occlusion periods. Decrease in U/Posm and U/Pcr gave further evidence of impairment of the concentrating mechanism. Changes in these indices were detectable during the period of occlusion, at a time when the medullary sodium gradient of the experimental kidney was not significantly altered from control, suggesting that the ability of the collecting-duct epithelium to respond to ADH had been impaired in the presence of an adequate osmolar gradient. Following occlusion, marked decrement of GFR in the face of adequate blood flow allowed for washout of the gradient, providing an additional factor responsible for the ensuing prolonged period of loss of concentrating ability.

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