Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects
Open Access
- 1 October 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 59 (10) , 1612-1620
- https://doi.org/10.1001/archneur.59.10.1612
Abstract
STRUCTURAL CHANGES of the brain are widely thought to be an inherent part of aging, with significant atrophy and white matter changes reported in 30% to 100% of the healthy elderly population.1,2 These changes seem to be related not only to age, but also to physical illnesses (eg, hypertension, diabetes mellitus3,4). They reach their highest prevalence in patients who have dementia,5 depression,6 and other neuropsychiatric disorders.7 Nevertheless, these structural features are not invariably associated with illness and are considered by some to be features of normal aging.1,8Keywords
This publication has 45 references indexed in Scilit:
- White matter abnormalities in mobility-impaired older personsNeurology, 2000
- Atrophy and High Intensity Lesions Complementary Neurobiological Mechanisms in Late-Life Major DepressionNeuropsychopharmacology, 2000
- White matter volumes and periventricular white matter hyperintensities in aging and dementiaNeurology, 2000
- Clinical Correlates of Ventricular and Sulcal Size on Cranial Magnetic Resonance Imaging of 3,301 Elderly PeopleNeuroepidemiology, 1999
- White Matter Hyperintensities and Gray Matter Lesions in Physically Healthy Depressed SubjectsAmerican Journal of Psychiatry, 1999
- NEUROIMAGING OF THE AGING BRAINNeurologic Clinics, 1998
- The spectrum of age-associated brain abnormalities: their measurement and histopathological correlatesPublished by Springer Nature ,1998
- Cognition and white matter hyperintensities in older depressed patientsAmerican Journal of Psychiatry, 1996
- Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly PeopleStroke, 1996
- CHANGES IN BRAIN FUNCTIONAL CONNECTIVITY IN ALZHEIMER-TYPE AND MULTI-INFARCT DEMENTIABrain, 1992