An Evaluation of Meprobamate in the Management of Selected Dermatoses

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Abstract
Introduction When the ataractic (tranquilizing) drugs were developed, they were alleged to offer alleviation of anxiety, emotional stress, and nervous tension, which so often play an important role in the production or perpetuation of various dermatoses. These drugs were claimed to be safe and free of side-effects, and it was claimed that they did not produce habituation. These factors stimulated us to evaluate the effects of meprobamate* in selected dermatoses, and the results of its administration in 260 patients are reported. Drug Meprobamate is a simple aliphatic compound and is the decarbonic ester of 3-0--toloxy-1,2-propanediol (mephenesin). Meprobamate produces muscle relaxation, and animal experiments have demonstrated it to have anticonvulsant action as well as the ability to tame disturbed animals. Only in excessive doses can the cerebral cortex be depressed.1,2 Review of Literature Enthusiasm for the drug following clinical studies has varied. Selling3 found it

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