FORMULATION OF THE PRINCIPAL FACTORS AFFECTING THE RATE OF UPTAKE OF CARBON MONOXIDE BY MAN

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Abstract
The rate of uptake of CO was constant with respect to blood concn. of COHb, up to values of 1/3 the equilibrium level, when air containing CO in the range 1 part-20 parts/10,000 is breathed by men at rest or engaged in moderate physical activity. An equation has been derived which serves as a means of estimating in man the degree of blood saturation with CO as a result of exposure to air containing this gas as follows: [image] The equation is valid for values of % COHb up to one third the equilibrium value for the air concn. of CO under consideration. Within this range A % COHb may be estimated within a degree of error whose standard deviation is [plus or minus]2.3% COHb. The fraction of CO removed from the inspired air by the blood was constant as uptake progressed, and the mean for a group of 12 men was 41.2% with a standard deviation of [plus or minus]4.4%. This value is somewhat lower than that observed by previous investigators.

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