Bromocriptine Therapy in Oligozoospermic Infertile Men

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Abstract
A prospective, randomized double-blind study with crossover using bromocriptine and placebo was performed on a group of 17 infertile males with idiopathic oligozoospermia. Twelve patients completed the duration of this study of 8 mo. by receiving 5 mg of bromocriptine/day for 4 mo. followed by 4 mo. of placebo or vice versa. Prior to treatment, the sperm count was 8.76 .+-. 1.32 (106/ml). The hormonal profile was performed prior to treatment and included estimation of prolactin, triiodothyronine, thyroxine TSH, testosterone, FSH, and plasma lutropin. Stimulation studies using LHRH and TRH were also performed. All hormonal estimations were within normal limits. Compared to placebo, bromocriptine had no significant effect on sperm analysis, or basic hormonal profile. The stimulation test with LHRH was unchanged except for the basic plasma testosterone, which increased. The prolactin decreased following the TRH stimulation. Two pregnancies were noted 4-6 wk following the end of treatment. Bromocriptine did not seem to be more effective than placebo in the treatment of idiopathic oliozoospermia.