Parathyroïdes et hypertension artérielle à l'acétate de désoxycorticostérone chez le rat

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Abstract
The importance of parathyroids in the development of mineralocorticoid hypertension in male Sprague-Dawley rats was studied. Ablation of the parathyroids 1 wk before deoxycorticosterone acetate (DOCA) + NaCl administration prevented development of hypertension (for 1 yr). But ablation of parathyroids 2 wk after the start of treatment had no effect on the development of arterial hypertension. Autotransplantation of parathyroids in thyroidectomized rats caused a recurrence of mineralocorticoid hypertension, which was completed after DL-thyroxine supplementation. Blood pressure levels were nearly the same as in DOCA sham rats. Parathyroid glands favor the establishment of mineralocorticoid hypertension in the rat. These results raise the question of the mechanism of action of parathyroid hormone in the hypertensive process.