Genetic contribution of the tumor necrosis factor region in guillain‐barré syndrome
- 1 November 1998
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 44 (5) , 815-818
- https://doi.org/10.1002/ana.410440517
Abstract
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain‐Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100–base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNFα production, existed in Campylobacter jejuni‐positive (Cj+) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNFα secretion in the development of c. jejuni‐related GBS.Keywords
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