Synthesis and Insecticidal Activity of 4-Substituted 1-Indanyl Chrysanthemates

Abstract
A variety of 4-substituted 1-indanyl chrysanthemates were prepared and their insecticidal activity was tested on American cockroachs. The activity of the chrysanthemates decreased in the following order: CH2=CHCH2>CH3OCH2≃CH3CH2≃HC≡CCH2>PhCH2, which was similar to that of p-substituted benzyl chrysanthemates against houseflies with the exception of the propargyl group. Formulation of the quantative structure-activity relationship by the Hansch’s program indicated that Van der Waals interaction between the chemical substance and the macromolecular in vivo play an important role in the 1-indanyl chrysanthemates.

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