Immune Responses to Varicella Zoster Virus Infections in Healthy Children

Abstract
The immune responses to varicella zoster virus were studied in 67 otherwise normal children participating in a placebo-controlledtrial of acyclovirfor the treatment of chickenpox. No differences were observed between acyclovir and placebogroups. Children were studied longitudinally, at onset of chickenpox, and at 1 month, 3 months, 1 year, and 3 years after infection. These data help define the natural history of the immune response to chickenpox in children.

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