In vitro toxicity test of 2‐cyanoacrylate polymers by cell culture method

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Abstract
The inhibition of Swiss 3T3 cell growth by the microspheres prepared from various 2‐cyanoacrylate polymers was investigated to assess their cell toxicity. Poly(ethoxyethyl 2‐cyanoacrylate) and poly(methyl 2‐cyanoacrylate) microspheres inhibited cell growth in a smaller amount than poly‐(isobutyl 2‐cyanoacrylate) and poly(ethyl 2‐cyanoacrylate) microspheres. The extent of cell growth inhibition by the microspheres decreased with the increasing molecular weight, regardless of the kind of polymers used. Every kind of the microspheres was degraded releasing formaldehyde in the culture medium. The cell growth inhibition by the medium containing the microspheres was observed within 24 h for poly(ethoxyethyl 2‐cyanoacrylate) and poly(methyl 2‐cyanoacrylate). The extent of inhibition was in a linear proportion with the amount of formaldehyde released. It is concluded that the cell toxicity of 2‐cyanoacrylate polymers is attributed to formaldehyde released upon polymer degradation.

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