REMOTE TRAUMA SENSITIZES HEPATIC MICROCIRCULATION TO ENDOTHELIN VIA CAVEOLIN INHIBITION OF eNOS ACTIVITY

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Abstract
This study addresses the microvascular mechanisms by which a remote, mild stress such as blunt trauma sensitizes the liver to injury. Rats received closed femur fracture (FFx), and 24 h later livers were isolated and perfused at a similar starting flow rate for assessment of vascular response to endothelin-1 (ET-1). Sinusoidal volumetric flow (QS), red blood cell velocity (VRBC), and sinusoidal diameter (Ds) were determined by intravital microscopy. Baseline portal resistance in livers from FFx rats was not changed. The FFx group showed a lower baseline VRBC (322.9 ± 26.4 and 207.3 ± 17.2 μm/s in sham and FFx,) and QS (28.4 ± 4.2 and 17.6 ± 2.1 pL/s in sham and FFx, P RBC