Cyclic Nucleotide Phosphodiesterase Type 5 Activity Limits Blood Flow to Hypoperfused Myocardium During Exercise
- 12 December 2000
- journal article
- other
- Published by Wolters Kluwer Health in Circulation
- Vol. 102 (24) , 2997-3002
- https://doi.org/10.1161/01.cir.102.24.2997
Abstract
Background—Nitric oxide (NO) causes vasodilation by stimulation of guanylate cyclase in vascular smooth muscle to produce cGMP. The resultant vasodilator effect is regulated by a family of cGMP pho...Keywords
This publication has 17 references indexed in Scilit:
- Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitroThe American Journal of Cardiology, 1999
- Effects of sildenafil citrate on human hemodynamicsThe American Journal of Cardiology, 1999
- Use of sildenafil (Viagra) in patients with cardiovascular diseaseJournal of the American College of Cardiology, 1999
- Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and manXenobiotica, 1999
- The Nitric Oxide Donor ITF 1129 Augments Subendocardial Blood Flow During Exercise-Induced Myocardial IschemiaJournal of Cardiovascular Pharmacology, 1997
- Nitrovasodilators ITF 296 and Isosorbide Dinitrate Exert Antiischemic Activity by Dilating Coronary Penetrating ArteriesJournal of Cardiovascular Pharmacology, 1995
- Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dogCardiovascular Research, 1994
- In vitro and in vivo interactions of nitrovasodilators and zaprinast, a cGMP-selective phosphodiesterase inhibitorEuropean Journal of Pharmacology, 1992
- Ca/CaM-Stimulated and cGMP-Specific Phosphodiesterases in Vascular and Non-Vascular TissuesPublished by Springer Nature ,1991
- Comparison of Hepatic Extraction of Insulin and Glucagon in Conscious and Anesthetized Dogs*Endocrinology, 1983