An example of major histocompatibility complex‐linked control of idiotypic interactions
- 1 January 1983
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 13 (1) , 82-85
- https://doi.org/10.1002/eji.1830130117
Abstract
Normal euthymic mice, injected i.v. with low doses of syngeneic monoclonal antibodies carrying “recurrent” idiotypes, develop a specific increase in numbers of splenic IgM plaque‐forming cells that are paratopically and idiotypically similar to the injected antibody. We have now studied the responsiveness to a C57BL/6 anti‐dextran α(1 → 6) and BALB/c anti‐TNP (trinitrophenyl) monoclonal antibodies in a variety of strains. It was found that such responses are controlled by two linkage groups, namely major histocompatibility complex (MHC) and Ig‐1.Keywords
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