Total Synthesis of Dihydrocinchonamine
- 3 January 1972
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 2 (1) , 55-61
- https://doi.org/10.1080/00397917208081642
Abstract
Cinchonamine (1) is the best known member of a small group of 2,2-indolquinuclidine alkaloids found in the bark of certain Cinchona and Remijia species 1 and in the leaves of Isertia hypoleuca2. Its isolationwas reported in 18813, the ambiguities was elucidated in 19504, and very recently5 th ambiguities concerning the absolute configuration at C-3 were resolved. Synthetic efforts resulted in the partial synthesis of cinchonamine6, dihydrocinchonamine7,8, and its 10-methoxy-analog5,9 from cinchonine, cinchonidine and quinine.Keywords
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