Catalymetric-thermometric titration of some derivatives of barbituric acid
- 1 January 1976
- journal article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 101 (1200) , 203-208
- https://doi.org/10.1039/an9760100203
Abstract
The compound barbitone, and the related compounds amylobarbitone, butobarbitone, hexobarbitone, phenobarbitone and quinalbarbitone, have been determined by catalymetric-thermometric titration involving an acid-base reaction in the analyte followed by a base-catalysed indicator reaction. The base-catalysed reactions used were the dimerisation of acetone and the polymerisation of acrylonitrile with dimethylformamide as a matrix diluent. The effects of excipients are reported, and a method of assay of dosage forms is proposed.Keywords
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