Extrahepatic synthesis of lipoproteins of plasma and chyle: role of the intestine.

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Abstract
In hepatectomized dogs there was incorporation of lysine-U-14c into all lipoprotein fractions but considerably less than in the intact animal. The highest rate of incorporation was in the D<1.019 lipoprotein fraction. In an abdominally eviscerated dog there was incorporation into the D 1.019-1.063 and D 1.063-1.21 fractions but not into the D <1.019 fraction. When the thoracic duct in hepatectomized dogs was cannulated and the lymph diverted, no activity was found in the D< 1.019 fraction of the plasma lipoproteins, but this fraction in the thoracic duct lymph was highly labeled. The liver and intestine are probably the sole sites of synthesis of the very low density lipoproteins.