Mechanism of protection against the delayed neurotoxic effects of organophosphorus esters.

  • 1 January 1976
    • journal article
    • Vol. 35  (1) , 73-4
Abstract
Delayed neurotoxic effects arise as a result of two distinct biochemical events: 1) inhibiton of neurotoxic esterase, and 2) 'aging' of inhibited enzyme. Protective agents undergo reaction 1 but cannot undergo 2. Reaction 2 may interfere with a normal physiological control mechanism.

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