Evaluation of the dosimetry of intravenously administered67Ga citrate from measurements of the distribution in male August-Marshall hybrid rats

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Abstract
An attempt has been made to predict the dosimetry of 67Ga citrate in man, from experimental data obtained on normal male August-Marshall hybrid rats. Activity in blood, pancreas, spleen, liver, kidneys, testes, lungs and femur, as well as whole-body retention, in the rat has been measured at various times following intravenous injection. The results obtained from the rat measurements indicate that with an injected dose of 2·5 mCi no organ of the body in man should receive a radiation dose of more than 2 rads. In addition, measurements were made on female rats bearing subcutaneously implanted tumours. There was considerable variation in tumour blood ratio, but this never exceeded the liver: spleen or kidney: blood ratios.

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