Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates
Open Access
- 1 February 2009
- journal article
- research article
- Published by Elsevier in Molecular Therapy
- Vol. 17 (2) , 327-333
- https://doi.org/10.1038/mt.2008.257
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Physical and infectious titers of helper-dependent adenoviral vectors: a method of direct comparison to the adenovirus reference materialMolecular Therapy, 2004
- Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In VivoJournal of Virology, 2004
- Acute Toxicity After High-Dose Systemic Injection of Helper-Dependent Adenoviral Vectors into Nonhuman PrimatesHuman Gene Therapy, 2004
- Improved system for helper-dependent adenoviral vector productionMolecular Therapy, 2003
- Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transferMolecular Genetics and Metabolism, 2003
- Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectorsMolecular Therapy, 2003
- Preexisting Immunity to Adenovirus in Rhesus Monkeys Fails To Prevent Vector-Induced ToxicityJournal of Virology, 2002
- Lethal Toxicity, Severe Endothelial Injury, and a Threshold Effect with High Doses of an Adenoviral Vector in BaboonsHuman Gene Therapy, 2002
- Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vectorProceedings of the National Academy of Sciences, 2001
- Liver-Directed Gene Transfer in Non-Human PrimatesHuman Gene Therapy, 1997