Effector activating determinants on IgG. II. Differentiation of the combining sites for C1q from those for cytotoxic K cells and neutrophils by plasmin digestion of rabbits IgG.
- 1 February 1974
- journal article
- Vol. 26 (2) , 303-10
Abstract
Plasmin digestion of rabbit IgG after pretreatment at low pH yields a fragment (Facb) which has lost the CH3 domain. A study of the biological activity of this fragment is described and the following conclusions are drawn: (1) Facb possesses the same antigen-combining capacity as the whole antibody; (2) C1 fixation is normal; (3) The capacity to sensitize target cells to lysis by cytotoxic K cells is lost; (4) Facb—antigen complexes are unable competitively to inhibit phagocytosis of sensitized bacteria by neutrophils.This publication has 15 references indexed in Scilit:
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