Radiation-induced chromosomal aberrations in the bone marrow of mice exposed to various doses of gamma radiation
- 1 June 1993
- journal article
- Published by Springer Nature in Radiation and Environmental Biophysics
- Vol. 32 (2) , 109-117
- https://doi.org/10.1007/bf01212797
Abstract
The occurrence of chromosomal aberrations was studied at 1–14 days post-exposure in female BALB/c mice exposed to various doses of gamma radiation. The frequency of abnormal cells, chromatid and chromosome breaks, dicentrics, centric rings, acentric fragments and total aberrations increased with exposure dose, and it was highest at 7 Gy. A peak was recorded on day 1 post-exposure with a gradual decline thereafter. The chromosomal aberration yield reached a nadir on day 14 post-irradiation, without restoration to the control level. The best fit for the present data was by a linear-quadratic relationship between dose of radiation and the frequency of chromosomal aberrations.Keywords
This publication has 19 references indexed in Scilit:
- Frequency of micronucleated cells in the mouse bone marrow after exposure to various doses of γ-radiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1990
- Chromosomal aberrations induced by low-dose γ-irradiation study of R-banded chromosomes of human lymphocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- Chromosomal aberrations and DNA repair ability of in vitro irradiated white blood cells of monkeys previously exposed to total body irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- Production of chromosome aberrations, micronuclei, and sister-chromatid exchanges by 24-keV epithermal neutrons in human G0 lymphocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989
- A Cytogenetic Comparison of the Responses of Mouse and Human Peripheral Blood Lymphocytes to 60 Co g RadiationRadiation Research, 1988
- Protection of mouse chromosomes against whole-body gamma irradiation by SH-compoundsThe British Journal of Radiology, 1986
- Cytogenetic Damage Induced in Human Lymphocytes by Low Doses of60co Gamma Rays Delivered at High and Low Dose RatesActa Radiologica: Oncology, 1986
- Protection Against Radiation Induced Chromosome Injury by Sulfhydryl CompoundsActa Radiologica: Oncology, 1985
- The Induction of Chromosome Aberrations in Human Lymphocytes byin VitroIrradiation with α-particles from Plutonium-239International Journal of Radiation Biology, 1980
- Radiation-induced Chromosome Aberrations in Chinese Hamster LeukocytesInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1972