Effects of Menopause on Trends of Serum Cholesterol, Blood Pressure, and Body Mass Index

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Abstract
Background To elucidate the impact of menopause on coronary risk factors, we determined the trends of serum cholesterol (mg/dL), blood pressure (BP, mm Hg), and body mass index (BMI, kg/m2) and investigated whether menopause affects these trends in women in Nagasaki, Japan. Methods and Results Trends of cholesterol, systolic BP (SBP), and BMI from 9 years before menopause through 9 years after menopause in 579 women with natural menopause (ranging in age from 40.2±3.1 to 57.9±3.1 years; age at menopause, 49.4±3.0 years) and 134 women with surgical menopause (hysterectomy with or without bilateral oophorectomy; ranging in age from 34.9±4.5 to 51.7±5.1 years; age at menopause, 42.9±5.0 years) and those in 579 and 134 age- and time-matched male subjects (ranging in age from 40.1±3.1 to 57.8±3.2 years and from 35.2±4.5 to 51.6±5.0 years, respectively) in Nagasaki were determined by rearrangement of the data from 1958 to 1989 with time of menopause as the datum line. Although cholesterol tended to increase wit...