The topically irritant substance: Essentials — bio-tests — predictions
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 11 (5) , 515-519
- https://doi.org/10.1007/bf02004715
Abstract
The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the ‘ordinary’ risks of many of the abundant marketed products for washing, cleaning etc. may be prdicted,without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.Keywords
This publication has 5 references indexed in Scilit:
- Irritant actions of unphysiological pH values. A controlled procedure to test for topical irritancyInflammation Research, 1979
- Evaluation of ocular irritation in the rabbit: Objective versus subjective assessmentToxicology and Applied Pharmacology, 1977
- Relative eye-injury potential of heavy-duty phosphate and non-phosphate laundry detergentsFood and Cosmetics Toxicology, 1972
- EYE IRRITATION FROM TOPICALLY APPLIED DRUGS AND COSMETICSOptometry and Vision Science, 1971
- ACID-BASE TOLERANCE OF THE CORNEAArchives of Ophthalmology (1950), 1944