AMYLOID DEPOSITION IN SYSTEMIC ORGANS IN LONG-TERM HEMODIALYSIS-PATIENTS

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  • 1 October 1987
    • journal article
    • research article
    • Vol. 28  (4) , 199-204
Abstract
It has not been yet elucidated whether, in long-term hemodialysis patients, amyloid deposition in the transverse carpal ligament (TCL) is a symptom of systemic amyloidosis or a localized one. In 2 patients amyloid deposition was noted in the TCL which had been resected at operation, and we observed amyloid deposits also in other organs at autopsy after their deaths. In the two patients, no diseases resulting in secondary amyloidosis were observed. The unlabeled antibody peroxidase-antiperoxidase method (PAP method) served to reveal the dposits of .beta.2-microglobulin (.beta.2M) in the TCL and other organs comparable to the Congo red positive area. And the Congo red staining for the amyloid protein after postassium permanganate treatment was preserved. According to these results, the carpal tunnel syndrome (CTS) in long-term hemodialysis was considered as a symptom of systemic amyloidosis. Amyloid was deposited mainly in the vessel walls and the deposition was not circumferential but segmental.