Estrogen Binding by Embryonic and Interembryonic Segments of the Rat Uterus Prior to Implantation

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Abstract
The capacity of embryonic and interembryonic segments of the uterus to bind 3H-estradiol was compared during the early stages of nidation in estrogen-treated "delayed implanting" rats. At the start of nidation, embryonic and interembryonic uterine segments were equally capable of binding 3H-estradiol. As implantation proceeded, however, the capacity of the embryonic segments (relative to that of interembryonic tissue) to bind newly administered 3H-estradiol decreased progressively. This deficiency was observed within 4 h, and by 16 h after the initiation of implantation, embryonic segments bound only one-fourth as much newly administered 3H-estradiol as was bound by interembryonic segments.