EFFECTS OF γ‐AMINOBUTYRIC ACID ON NERVE TERMINAL EXCITABILITY IN A SLICE PREPARATION OF CUNEATE NUCLEUS
Open Access
- 19 July 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 63 (3) , 503-507
- https://doi.org/10.1111/j.1476-5381.1978.tb07804.x
Abstract
1 Superfusion of a slice preparation of the rat cuneate nucleus with γ-aminobutyric acid (GABA) depolarized the afferent nerve fibres and increased their excitability. However, before the depolarization had reached its peak the increased excitability reversed to a decreased excitability, an effect which outlasted the depolarization. 2 Both components of the GABA excitability response were dose-related, CI “-dependent and antagonized by bicuculline. 3 Possible mechanisms underlying the sequence of excitability changes are discussed.Keywords
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