Action of prednisolone on3H-catecholamine synthesis in rat adrenals during physical fatigue

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Abstract
The effect of prednisolone on the synthesis of 3H-catecholamines by the adrenals of control and rats swimming for 8 h was studied in experiments in vitro with the use of 3H-thyrosine as precursor. In swimming rats, the synthesis of 3H-noradrenaline [norepinephrine, NE] and 3H-adrenaline [epinephrine, E] is inhibited by 25%, while the synthesis of 3H-dopamine remains unchanged. Addition of prednisolone to the incubation medium does not affect the rate of 3H-catecholamine synthesis by the adrenals of intact rats. Addition of prednisolone to the adrenals of swimming rats leads to the stimulation of synthesis of 3H-NE and 3H-E by 72%, while the synthesis of 3H-dopamine gets stimulated by 56% relative to the synthesis rate of 3H-catecholamines during swimming. In the latter case the rate of 3H-catecholamine synthesis significantly exceeds the control level.