The mechanism of the inhibitory action of salicylate on glutamyl-transfer ribonucleic acid synthetase in vitro
- 1 August 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (8) , 590-594
- https://doi.org/10.1111/j.2042-7158.1971.tb08722.x
Abstract
Salicylate inhibits glutamyl-transfer ribonucleic acid synthetase by simple competitive inhibition with respect to glutamate and mixed competitive-non-competitive inhibitions with ATP and tRNA. It is suggested that competition between salicylate and amino-acid explains the variable inhibition of the synthetases by the drugs in vitro. The action of salicylate is consistent with a mechanism for glutamyl-tRNA formation involving a concerted interaction of all three substrates. The drug may selectively interfere with protein synthesis in vivo.Keywords
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