In Vitro Biosynthesis of Human Renin: Evidence for a High Molecular Weight Form
- 1 January 1982
- journal article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 4 (11-12) , 2019-2026
- https://doi.org/10.3109/10641968209062367
Abstract
Primary cultures of human chorionic cells have been developed. They secrete an inactive form of renin which can be activated by trypsin treatment. in biosynthesis experiments forming labelled renin the inactive renin exhibited a molecular weight (54 KD) higher than active kidney renin (44 KD). The same high molecular weight renin was obtained during biosynthesis experiments performed on tissue slices of human infarcted kidney. Therefore it is postulated that 54 KD biosynthetized renin might be the precursor of active renin.Keywords
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