Low birth weight across generations

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Abstract
The relationship between maternal birth weight and infant birth weight was studied in the Buffalo [New York, USA] cohort of the Collaborative Perinatal Project (n = 1348). Regression techniques were used to control for confounders. Compared with infants of mothers who had weighed 8 lb or more at birth, infants of mothers who had weighed 6-7.9 lb, 4-5.9 lb, and < 4 lb at birth were 99 g, 244 g, and 170 g lighter, respectively. The adjusted odds ratios of giving birth to an infant of birth weight < 2500 g, with mothers of birth weight .gtoreq. 8 lb as the reference group, were 3.46 and 1.66 for mothers of birth weight 4-5.9 lb and 6-7.9 lb, respectively. There were no infants < 2500 g among the 24 women who had weighed < 4 lb at birth. A possible role of genetic and familial factors in determining birth weight is suggested.

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