Induction of microsomal enzymes in rat liver by oxcarbazepine, 10,11-dihydro-10-hydroxy-carbamazepine and carbamazepine
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (8) , 951-956
- https://doi.org/10.3109/00498258709044193
Abstract
The effects of the new anti-epileptic drug, oxcarbazepine, its major metabolite in man 10,11-dihydro-10-hydroxy-carbamazepine, and carbamazepine, on hepatic microsomal enzyme activities have been studied in rats repeated administration of equimolar doses. All three compounds caused a qualitatively similar induction of the mono-oxygenase system, the greatest increase being observed in the activity of 4-nitroanisole O-demethylase. Oxcarbazepine is as potent as carbamazepine, while 10,11-dihydro-10-hydroxy-carbamazepine is a weak inducer. The observation that oxcarbazepine is a potent inducer in rats but not in man is explained by the species differences in its metabolism.This publication has 10 references indexed in Scilit:
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