Relations Entre La 3-Méthoxytyramine Urinaire Et Le Métabolisme Périphérique De La Dopamine Chez L'Homme Et Chez L'Enfant

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Abstract
3-Methoxytyramine (3-MT), the direct metabolite of dopamine (DA), is present in human urines at birth. The rate of its urinary excretion (μg/24 h) increases highly from birth to 12 months of age; in the next period of infancy, the increase is slower and parallel to that of creatininury; after 15 years, the urinary amounts of 3-MT remain nearly constant, with advancing age. The analysis of the possible sources of urinary 3-MT, lead us to suggest that this compound has essentially a peripheral origin. On the other hand the comparison between urinary data of 3-MT and DA in normal infants and adult subjects has shown that 3-MT excretion is less affected by dietary input than DA itself, so that it can be concluded that urinary 3-MT is a better indication of peripheral dopaminergic activity than urinary DA, chiefly in the young child.
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