LACK OF EFFECT OF A GRANULOCYTE PROLIFERATION INHIBITOR ON THEIR COMMITTED PRECURSOR CELLS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 26  (3) , 163-169
Abstract
Using the agar culture technique [in mice], the effect was measured of granulocyte extracts GCE (and of erythrocyte-RCE and lymph node extracts-LNE) on the growth and proliferation of the committed granulocytic precursor cells, CFU-C was measured. Their effects on the proliferation of the developing colony cells and on the ultimate cell production in the colonies were determined. GCE apparently has no effect on the growth or proliferative activity on the CFU-C. It does reduce both the autoradiographic labeling indices of the developing colony cells and the net colony cellularities, acting as a cell cycle modulator. These are effects specific to the GCE since, at the dose levels used, neither RCE nor LNE affected these measurements.

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