Comparison of 3 Chelating Agents in Treatment of Experimental Manganese Poisoning
- 1 March 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 100 (3) , 570-573
- https://doi.org/10.3181/00379727-100-24700
Abstract
Summary Three chelating agents of the polyamino polycarboxylic acid type, ethylene-diaminetetraacetic acid, diethylenetriamine-pentaacetic acid, and ethylene bis(α-imino-o-hydroxyphenylacetic acid) have been compared in treatment of acute experimental manganese poisoning. EBAA had no therapeutic value, whereas both EDTA and DTPA provided significant protection to rats given lethal amounts of manganese gluconate. It is shown that DTPA is somewhat more effective than EDTA.Keywords
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