Regulation of Msx genes by a Bmp gradient is essential for neural crest specification
Open Access
- 29 December 2003
- journal article
- Published by The Company of Biologists in Development
- Vol. 130 (26) , 6441-6452
- https://doi.org/10.1242/dev.00878
Abstract
There is evidence in Xenopus and zebrafish embryos that the neural crest/neural folds are specified at the border of the neural plate by a precise threshold concentration of a Bmp gradient. In order to understand the molecular mechanism by which a gradient of Bmp is able to specify the neural crest, we analyzed how the expression of Bmp targets, the Msx genes, is regulated and the role that Msx genes has in neural crest specification.Keywords
This publication has 87 references indexed in Scilit:
- Wnt–frizzled signaling in the induction and differentiation of the neural crestBioEssays, 2003
- SnailprecedesSlugin the genetic cascade required for the specification and migration of theXenopusneural crestDevelopment, 2003
- Characterization of a Smad Motif Similar to Drosophila Mad in the Mouse Msx 1 PromoterBiochemical and Biophysical Research Communications, 2002
- A Nonsense Mutation in MSX1 Causes Witkop SyndromeAmerican Journal of Human Genetics, 2001
- Effective targeted gene ‘knockdown’ in zebrafishNature Genetics, 2000
- Structural and Functional Analysis of MouseMsx1Gene Promoter: Sequence Conservation with HumanMSX1Promoter Points at Potential Regulatory ElementsDNA and Cell Biology, 1998
- A Minimal Murine Msx-1 Gene PromoterPublished by Elsevier ,1997
- Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activityCell, 1994
- Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth developmentCell, 1993
- The origins of neural crest cells in the axolotlDevelopmental Biology, 1990