Relationship between Citrate and Complexed Calcium in Plasma

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Abstract
A low P, adequate Ca diet was modified so that it was either acidotic or alkalotic. Rats fed this diet consistently exhibited an elevation of plasma and urinary Ca. Plasma and urinary citrate tended to parallel the rise in Ca. While the variations in Ca were independent of the acid-base balance the increases in citrate were only observed in alkalotic rats; no change in citrate was detected in acidosis. Using these diets to produce a hypercalcemia with and without a hyper-citremia measurements were made of the protein-bound, ionized, and complexed plasma calcium fractions. Complexed Ca varied directly with the plasma citrate level and the evidence suggested that most of the observed rise in plasma citrate could be accounted for by the formation of a Ca citrate complex. As predicted from the mass law equation, the ratio between ionized and total plasma Ca and between protein-bound and total plasma Ca remained constant when the total plasma Ca was elevated. The ratio between complexed and total plasma Ca was disproportionly high in alkalosis and low in acidosis.

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