Spatial proximity of translocation-prone gene loci in human lymphomas
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- 15 June 2003
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 34 (3) , 287-291
- https://doi.org/10.1038/ng1177
Abstract
Cancer cells frequently have disease-specific chromosome rearrangements1,2,3,4. It is poorly understood why translocations between chromosomes recur at specific breakpoints in the genome. Here we provide evidence that higher-order spatial genome organization is a contributing factor in the formation of recurrent translocations. We show that MYC, BCL and immunoglobulin loci, which are recurrently translocated in various B-cell lymphomas, are preferentially positioned in close spatial proximity relative to each other in normal B cells. Loci in spatial proximity are non-randomly positioned towards the nuclear interior in normal B cells. This locus proximity is the consequence of higher-order genome structure rather than a property of individual genes. Our results suggest that the formation of specific translocations in human lymphomas, and perhaps other tissues, is determined in part by higher-order spatial organization of the genome.Keywords
This publication has 27 references indexed in Scilit:
- Chromosome positioning in the interphase nucleusTrends in Cell Biology, 2002
- Replication and Subnuclear Location Dynamics of the Immunoglobulin Heavy-Chain Locus in B-Lineage CellsMolecular and Cellular Biology, 2002
- Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte DevelopmentScience, 2002
- Human Genome and Diseases:¶Double-strand breaks and translocations in cancerCellular and Molecular Life Sciences, 2002
- Translocations involving c-myc and c-myc functionOncogene, 2001
- Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human CellsScience, 2000
- The influence of the cell cycle, differentiation and irradiation on the nuclear location of the abl, bcr and c-myc genes in human leukemic cellsLeukemia Research, 2000
- Nuclear topography of the c-myc gene in human leukemic cellsGene, 2000
- Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA – PCR analyses of biopsy samplesOncogene, 1999
- THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIASAnnual Review of Genetics, 1998