Lipase catalysed regio- and enantio-selective hydrolysis: molecular recognition phenomenon and synthesis of (R)-dimorphecolic acid
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1197-1198
- https://doi.org/10.1039/c39910001197
Abstract
Molecular recognition has been observed in hydrolysis of racemic esters of (E)-9-acetoxy-11-bromoundec-10-enoic acid by a lipase of Candida cylindracea(E.C. 3.1.1.3) where optically active (R-(E)-9-acetoxy-11-bromoundec-10-enoic acid [enantiomeric excess (e.e.) > 99%] was obtained which was used in synthesis of (R)-dimorphecolic acid.Keywords
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