Studies of Anabolic Steroids

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Abstract
Oxandrolone is a new experimental anabolic steroid chemically related to testosterone and described structurally as 17-beta-hydroxy-17-alpha-methyl-2-oxa-5 -alpha-androstan-3-one. This compound, which was synthesized by Pappo and Jung,1is unique among anabolic steroids in that it has an oxygen atom substituted for the carbon atom at position number 2 of the phenanthrene nucleus; all previously available anabolic steroids have had an intact phenanthrene nucleus and have differed from testosterone in structure only by alterations in the numbers and positions of atoms or chemical groups attached to this nucleus. Preliminary studies of oxandrolone in animals suggested that this compound has anabolic effects similar to norethandrolone but androgenicity less than 1% of that seen with testosterone.2In adult human subjects, as indicated by the "steroid protein activity index (SPAI)," Albanese, Lorenze, and Orto3,4found oxandrolone to compare favorably in protein anabolic properties with the most potent anabolic steroids tested: testosterone propionate,

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