CELL TYPES IN LONG-TERM PROPAGABLE CULTURES OF RAT LIVER*

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Abstract
Under the conditions of this experiment, propagable hepatic epithelial cells in long-term culture were derived from a small, nonparenchymal precursor cell present in the liver in vivo. Progeny of the nonparenchymal precursor cell weakly expressed some hepatocyte-like properties in culture. Hepatocytes were not clonogenic under the conditions of this experiment. Propagable hepatic epithelial cells in long-term culture probably originate from hepatic stem cells in vivo. Terminal biliary ductular cells are facultative stem cells for hepatocytes.