Homologous Association of Oppositely Imprinted Chromosomal Domains
- 3 May 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5262) , 725-728
- https://doi.org/10.1126/science.272.5262.725
Abstract
Human chromosome 15q11-q13 encompasses the Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) loci, which are subject to parental imprinting, a process that marks the parental origin of certain chromosomal subregions. A temporal and spatial association between maternal and paternal chromosomes 15 was observed in human T lymphocytes by three-dimensional fluorescence in situ hybridization. This association occurred specifically at the imprinted 15q11-q13 regions only during the late S phase of the cell cycle. Cells from PWS and AS patients were deficient in association, which suggests that normal imprinting involves mutual recognition and preferential association of maternal and paternal chromosomes 15.Keywords
This publication has 32 references indexed in Scilit:
- Domain organization of allele–specific replication within the GABRB3 gene cluster requires a biparental 15q11–13 contributionNature Genetics, 1995
- Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15Nature Genetics, 1995
- Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control regionNature Genetics, 1994
- Chromosome pairing via multiple interstitial interactions before and during meiosis in yeastCell, 1994
- Angelman syndrome due to paternal uniparental disomy of chromosome 15: A milder phenotype?American Journal of Medical Genetics, 1994
- Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal regionNature Genetics, 1994
- The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis.The Journal of cell biology, 1993
- Trans-sensing effects from Drosophila to humansCell, 1991
- Chromosome topology in mammalian interphase nucleiExperimental Cell Research, 1991
- Transvection and long‐distance gene regulationBioEssays, 1990