Chronic Poliovirus Infection of Cocultivated Monkey Cells Harboring the Mason-Pfizer Monkey Virus2

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Abstract
We studied a cell system (CMMT), consisting of embryonic rhesus monkey cells harboring the Mason-Pfizer monkey virus (M-PMV), periodically cocultivated with fresh embryonic rhesus cells before, but not after, our receipt of the culture. It contained cells that were either sensitive or completely resistant to cytolysis by poliovirus, types 1 and 3. Cultures derived from poliovirus-surviving cells (CMMT-P) continued to produce M-PMV and supported a low-grade, chronic infection with poliovirus. Karyology, isoenzyme analyses, specific immunoRuorescence tests, and ribosomal RNA values confirmed the primate origin of CMMT cells but could not distinguish between them and CMMT-P cells.

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