Human rheumatoid factor cross‐idiotypes

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Abstract
The BLA cross‐idiotype (XId) is present on a unique subset of rheumatoid factors (RF) that cross‐react with DNA‐histone. In this study, prototype Bla monoclonal RF was shown from serologic investigations and N‐terminal amino acid sequence analysis to have distinct k chains related to the Vk III subgroup and VH4 heavy chains. The amino terminus of the heavy chain was cyclized, rendering the protein resistant to Edman degradation and providing a possible investigator bias to the published Ig sequence data to date. This appears to be the first definitive report of a serum IgM that expresses the VH4 gene. RF with DNA cross‐reactivity have been reported to be produced by human and mouse cloned cells that have the VH4 or homologous mouse Vh36–60 gene.

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